/* ============================================================
   ARIANE - stylesheet
   Clean, professional, accessible
   ============================================================ */

:root {
    --color-bg:         #f8f9fa;
    --color-surface:    #ffffff;
    --color-border:     #dee2e6;
    --color-text:       #212529;
    --color-text-muted: #6c757d;
    --color-primary:    #2563eb;
    --color-primary-hover: #1d4ed8;
    --color-error:      #dc3545;
    --color-warning:    #f59e0b;
    --color-success:    #10b981;

    --class-5: #dc2626;
    --class-4: #ea580c;
    --class-3: #6b7280;
    --class-2: #2563eb;
    --class-1: #059669;

    --radius:  6px;
    --shadow:  0 1px 3px rgba(0,0,0,0.08);
    --font:    -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;
    --mono:    "SFMono-Regular", Consolas, "Liberation Mono", Menlo, monospace;
}

* { box-sizing: border-box; margin: 0; padding: 0; }

body {
    font-family: var(--font);
    color: var(--color-text);
    background: var(--color-bg);
    line-height: 1.6;
}

.container {
    max-width: 960px;
    margin: 0 auto;
    padding: 0 1.5rem;
}

/* ── Header ─────────────────────────────────────────────────── */
header {
    background: var(--color-surface);
    border-bottom: 1px solid var(--color-border);
    padding: 2rem 0 1.5rem;
}

header h1 {
    font-size: 1.8rem;
    font-weight: 700;
    letter-spacing: 0.04em;
    color: var(--color-primary);
}

header .subtitle {
    font-size: 0.9rem;
    color: var(--color-text-muted);
    margin-top: 0.2rem;
}

header .version {
    font-size: 0.8rem;
    color: var(--color-text-muted);
    margin-top: 0.1rem;
}

/* ── Search form ────────────────────────────────────────────── */
.search-section {
    background: var(--color-surface);
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    padding: 1.5rem;
    margin: 2rem 0 1rem;
    box-shadow: var(--shadow);
}

.form-row {
    display: flex;
    gap: 1rem;
    align-items: flex-end;
    flex-wrap: wrap;
}

.form-group {
    display: flex;
    flex-direction: column;
}

.form-group label {
    font-size: 0.8rem;
    font-weight: 600;
    color: var(--color-text-muted);
    margin-bottom: 0.3rem;
}

.form-group .optional {
    font-weight: 400;
    color: #adb5bd;
}

.form-group-wide {
    flex: 1;
    min-width: 200px;
}

.form-group-btn {
    flex-shrink: 0;
}

input, select {
    padding: 0.55rem 0.75rem;
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    font-size: 0.95rem;
    font-family: var(--mono);
    background: var(--color-bg);
}

input:focus, select:focus {
    outline: none;
    border-color: var(--color-primary);
    box-shadow: 0 0 0 2px rgba(37, 99, 235, 0.15);
}

button {
    padding: 0.55rem 1.5rem;
    background: var(--color-primary);
    color: white;
    border: none;
    border-radius: var(--radius);
    font-size: 0.95rem;
    font-weight: 600;
    cursor: pointer;
    transition: background 0.15s;
}

button:hover:not(:disabled) {
    background: var(--color-primary-hover);
}

button:disabled {
    opacity: 0.6;
    cursor: not-allowed;
}

.input-hint {
    font-size: 0.85rem;
    margin-top: 0.5rem;
}

.field-hint {
    color: var(--color-text-muted);
    font-size: 0.72rem;
    font-weight: 400;
    line-height: 1.35;
}

/* ── Progress bar ───────────────────────────────────────────── */
.progress-container {
    margin: 1rem 0;
}

.progress-bar {
    height: 4px;
    background: var(--color-border);
    border-radius: 2px;
    overflow: hidden;
}

.progress-fill {
    height: 100%;
    background: var(--color-primary);
    transition: width 0.4s ease;
}

.progress-text {
    font-size: 0.8rem;
    color: var(--color-text-muted);
    margin-top: 0.3rem;
}

/* ── Classification result ──────────────────────────────────── */
.result-section {
    margin: 1.5rem 0 3rem;
}

.classification-header {
    display: flex;
    gap: 1.5rem;
    align-items: center;
    background: var(--color-surface);
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    padding: 1.5rem;
    box-shadow: var(--shadow);
}

.class-badge {
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    width: 80px;
    height: 80px;
    border-radius: 50%;
    color: white;
    flex-shrink: 0;
}

.class-badge .class-number { font-size: 1.6rem; font-weight: 700; line-height: 1; }
.class-badge .class-label  { font-size: 0.6rem; font-weight: 600; text-transform: uppercase; letter-spacing: 0.04em; }

.class-5 { background: var(--class-5); }
.class-4 { background: var(--class-4); }
.class-3 { background: var(--class-3); }
.class-2 { background: var(--class-2); }
.class-1 { background: var(--class-1); }

.class-details h2 {
    font-size: 1.1rem;
    font-family: var(--mono);
    font-weight: 500;
}

.class-details p { font-size: 0.85rem; color: var(--color-text-muted); }
.class-note { font-style: italic; }
.evidence-flag { color: var(--color-success); font-weight: 500; }

/* ── Tables ─────────────────────────────────────────────────── */
.criteria-section, .warnings-section, .external-section, .vus-section,
.rna-review-section, .splice-ps1-review-section, .initiation-review-section,
.manual-evidence-section, .sources-section {
    background: var(--color-surface);
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    padding: 1.2rem 1.5rem;
    margin-top: 1rem;
    box-shadow: var(--shadow);
}

h3 {
    font-size: 0.95rem;
    font-weight: 600;
    margin-bottom: 0.8rem;
    color: var(--color-text);
}

.collapsible {
    cursor: pointer;
    user-select: none;
}

.collapsible:hover {
    color: var(--color-primary);
}

table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.85rem;
}

th {
    text-align: left;
    padding: 0.5rem 0.75rem;
    border-bottom: 2px solid var(--color-border);
    font-weight: 600;
    color: var(--color-text-muted);
    font-size: 0.78rem;
    text-transform: uppercase;
    letter-spacing: 0.03em;
}

td {
    padding: 0.5rem 0.75rem;
    border-bottom: 1px solid #f1f3f5;
}

.reason-cell {
    font-size: 0.8rem;
    color: var(--color-text-muted);
    max-width: 400px;
}

.criterion-badge {
    display: inline-block;
    padding: 0.15rem 0.5rem;
    background: #e9ecef;
    border-radius: 3px;
    font-family: var(--mono);
    font-size: 0.8rem;
    font-weight: 600;
}

.detail-table td:first-child {
    font-weight: 600;
    color: var(--color-text-muted);
    width: 200px;
}

.submitter-table .enigma-row {
    background: #fef3c7;
}

.clinvar-stars {
    color: #d97706;
    font-size: 1.05rem;
    letter-spacing: 0.08rem;
}

.star-count {
    color: var(--color-text-muted);
    margin-left: 0.35rem;
    font-size: 0.78rem;
}

.curated-status {
    display: inline-block;
    border-radius: 99px;
    padding: 0.15rem 0.5rem;
    background: #fef3c7;
    color: #92400e;
    font-size: 0.72rem;
    font-weight: 600;
}

.conflict-flag {
    color: var(--color-error);
    font-weight: 500;
}

h4 {
    font-size: 0.85rem;
    font-weight: 600;
    margin: 1rem 0 0.5rem;
    color: var(--color-text-muted);
}

.panel-intro {
    margin: -0.3rem 0 0.8rem;
    color: var(--color-text-muted);
    font-size: 0.82rem;
    line-height: 1.5;
}

.manual-criterion-card {
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    margin: 0.75rem 0;
    overflow: hidden;
}

.manual-card-heading {
    background: #f8fafc;
    padding: 0.75rem 0.9rem;
}

.manual-card-heading label {
    display: flex;
    align-items: center;
    gap: 0.55rem;
    cursor: pointer;
}

.manual-card-body {
    padding: 0.9rem;
}

.threshold-note {
    padding: 0.65rem 0.75rem;
    background: #eef4ff;
    border-left: 3px solid var(--color-primary);
    font-size: 0.8rem;
    margin-bottom: 0.8rem;
}

.reference-helper {
    margin-bottom: 0.8rem;
}

.curation-warning {
    background: #fff7ed;
    border-left: 3px solid var(--color-warning);
    color: #7c2d12;
    font-size: 0.78rem;
    line-height: 1.4;
    margin: 0.65rem 0;
    padding: 0.55rem 0.7rem;
}

.manual-input-grid,
.audit-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(180px, 1fr));
    gap: 0.75rem;
    margin-bottom: 0.8rem;
}

.manual-input-grid label,
.audit-grid label,
.full-width-label,
.strength-row label {
    display: flex;
    flex-direction: column;
    gap: 0.3rem;
    font-size: 0.78rem;
    font-weight: 600;
    color: var(--color-text-muted);
}

.manual-input-grid .checkbox-label {
    flex-direction: row;
    align-items: center;
    gap: 0.5rem;
    padding-top: 1.4rem;
}

.manual-input-grid .checkbox-label input {
    width: auto;
}

.manual-input-grid input,
.audit-grid input,
.full-width-label textarea,
.strength-row select {
    padding: 0.5rem 0.6rem;
    border: 1px solid var(--color-border);
    border-radius: 4px;
    background: white;
    color: var(--color-text);
    font: inherit;
}

.strength-row {
    display: flex;
    align-items: end;
    justify-content: space-between;
    gap: 1rem;
    flex-wrap: wrap;
    font-size: 0.82rem;
    margin-bottom: 0.8rem;
}

.checklist-details {
    background: #fafafa;
    border: 1px solid var(--color-border);
    border-radius: 4px;
    padding: 0.65rem 0.75rem;
    margin-bottom: 0.8rem;
    font-size: 0.8rem;
}

.checklist-details summary {
    cursor: pointer;
    font-weight: 600;
}

.checklist-details p {
    margin-top: 0.5rem;
    line-height: 1.45;
}

.full-width-label {
    margin-top: 0.65rem;
}

.audit-grid {
    margin-top: 1rem;
}

.amended-result {
    margin-top: 1rem;
    border: 1px solid #bfdbfe;
    border-radius: var(--radius);
    background: #eff6ff;
    padding: 1rem;
}

.amended-result-heading {
    display: flex;
    align-items: center;
    gap: 1rem;
}

.class-badge.compact {
    width: 64px;
    height: 64px;
}

.working-result-warning {
    margin-top: 0.75rem;
    font-size: 0.78rem;
    color: var(--color-text-muted);
}

.manual-result-table {
    margin-top: 0.75rem;
    background: white;
}

.override-flag {
    display: inline-block;
    margin-left: 0.35rem;
    padding: 0.1rem 0.35rem;
    border-radius: 3px;
    background: #ffedd5;
    color: #9a3412;
    font-size: 0.68rem;
    font-weight: 600;
}

.audit-summary {
    margin: 0.75rem 0;
    font-size: 0.78rem;
    color: var(--color-text-muted);
}

.btn-secondary {
    border: 1px solid var(--color-primary);
    border-radius: 4px;
    padding: 0.5rem 0.75rem;
    background: white;
    color: var(--color-primary);
    cursor: pointer;
    font-weight: 600;
}

.source-list {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
    gap: 0.75rem;
}

.source-item {
    border: 1px solid var(--color-border);
    border-radius: 4px;
    padding: 0.75rem;
}

.source-item a {
    font-weight: 600;
    color: var(--color-primary);
}

.source-item p {
    margin-top: 0.3rem;
    font-size: 0.78rem;
    color: var(--color-text-muted);
    line-height: 1.4;
}

/* ── Warnings ───────────────────────────────────────────────── */
.warning {
    font-size: 0.82rem;
    color: var(--color-warning);
    padding: 0.3rem 0;
    padding-left: 1rem;
    border-left: 3px solid var(--color-warning);
    margin-bottom: 0.3rem;
}

/* ── Footer ─────────────────────────────────────────────────── */
footer {
    background: var(--color-surface);
    border-top: 1px solid var(--color-border);
    padding: 1.5rem 0;
    margin-top: 3rem;
}

footer p {
    font-size: 0.75rem;
    color: var(--color-text-muted);
    text-align: center;
}

/* ── Responsive ─────────────────────────────────────────────── */
@media (max-width: 640px) {
    .form-row { flex-direction: column; }
    .classification-header { flex-direction: column; text-align: center; }
}

/* ── Narrative summary ───────────────────────────────────────── */
.narrative-section {
    background: #f0f7ff;
    border-left: 4px solid var(--color-primary);
    border-radius: 0 var(--radius) var(--radius) 0;
    padding: 1rem 1.25rem;
    margin-bottom: 1.25rem;
}

.narrative-text {
    font-size: 0.9rem;
    line-height: 1.65;
    color: var(--color-text);
    margin-bottom: 0.5rem;
}

.alphamissense-row {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin-top: 0.6rem;
    padding-top: 0.6rem;
    border-top: 1px solid #cce0ff;
    flex-wrap: wrap;
}

.am-label {
    font-size: 0.78rem;
    font-weight: 600;
    color: var(--color-text-muted);
    text-transform: uppercase;
    letter-spacing: 0.04em;
}

.am-score {
    font-family: var(--mono);
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-text);
}

.am-class {
    font-size: 0.78rem;
    font-weight: 600;
    padding: 0.1rem 0.5rem;
    border-radius: 99px;
    color: #fff;
}

.am-likely-pathogenic { background: var(--class-4); }
.am-ambiguous          { background: var(--class-3); }
.am-likely-benign      { background: var(--class-2); }

.am-note {
    font-size: 0.73rem;
    color: var(--color-text-muted);
    font-style: italic;
}

.vus-section {
    border-left: 4px solid var(--class-3);
}

.vus-strong-pathogenic-one-step-short,
.vus-ps3-pp3-one-step-short,
.vus-pvs1-needs-support,
.vus-conflicting-pvs1-bs3,
.vus-conflicting-pp3-bs3,
.vus-mixed-benign-pathogenic-evidence,
.vus-computational-evidence-not-enough {
    border-left-color: var(--class-5);
    background: #fff5f5;
    border-color: #fecaca;
}

.vus-strong-pathogenic-one-step-short h3,
.vus-ps3-pp3-one-step-short h3,
.vus-pvs1-needs-support h3,
.vus-conflicting-pvs1-bs3 h3,
.vus-conflicting-pp3-bs3 h3,
.vus-mixed-benign-pathogenic-evidence h3,
.vus-computational-evidence-not-enough h3 {
    color: #991b1b;
}

.vus-strong-pathogenic-one-step-short .vus-next strong,
.vus-ps3-pp3-one-step-short .vus-next strong,
.vus-pvs1-needs-support .vus-next strong,
.vus-conflicting-pvs1-bs3 .vus-next strong,
.vus-conflicting-pp3-bs3 .vus-next strong,
.vus-mixed-benign-pathogenic-evidence .vus-next strong,
.vus-computational-evidence-not-enough .vus-next strong {
    color: #b91c1c;
}

.vus-strong-pathogenic-one-step-short .vus-meta,
.vus-ps3-pp3-one-step-short .vus-meta,
.vus-pvs1-needs-support .vus-meta,
.vus-conflicting-pvs1-bs3 .vus-meta,
.vus-conflicting-pp3-bs3 .vus-meta,
.vus-mixed-benign-pathogenic-evidence .vus-meta,
.vus-computational-evidence-not-enough .vus-meta {
    color: #7f1d1d;
}

.vus-summary,
.vus-next,
.vus-meta {
    font-size: 0.86rem;
    color: var(--color-text);
    margin-bottom: 0.4rem;
}

.vus-meta {
    color: var(--color-text-muted);
    font-style: italic;
}

.rna-review-section {
    border-left: 4px solid var(--color-primary);
}

.splice-ps1-review-section {
    border-left: 4px solid var(--color-warning);
}

.rna-review-section h3,
.splice-ps1-review-section h3 {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    flex-wrap: wrap;
}

.priority-pill {
    display: inline-block;
    border-radius: 99px;
    padding: 0.1rem 0.45rem;
    background: #eef4ff;
    color: var(--color-primary);
    font-size: 0.7rem;
    font-weight: 700;
    text-transform: uppercase;
}

.rna-summary,
.rna-branches,
.rna-limitations,
.review-summary,
.review-branches,
.review-limitations,
.review-source {
    font-size: 0.84rem;
    color: var(--color-text);
    margin-bottom: 0.55rem;
}

.review-source {
    padding: 0.55rem 0.7rem;
    border: 1px solid #fed7aa;
    border-radius: 4px;
    background: #fff7ed;
    color: #7c2d12;
}

.rna-grid,
.review-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
    gap: 1rem;
    margin: 0.75rem 0;
}

.rna-grid ul,
.review-grid ul {
    padding-left: 1.1rem;
}

.rna-grid li,
.review-grid li {
    font-size: 0.8rem;
    color: var(--color-text-muted);
    margin-bottom: 0.35rem;
    line-height: 1.45;
}

.rna-review-section a,
.splice-ps1-review-section a {
    color: var(--color-primary);
    font-size: 0.82rem;
    font-weight: 600;
}

/* ── Mode tabs ───────────────────────────────────────────────── */
.mode-tabs {
    display: flex;
    gap: 0.25rem;
    margin-bottom: 1.5rem;
    border-bottom: 2px solid var(--color-border);
    padding-bottom: 0;
}

.tab-btn {
    background: none;
    border: none;
    padding: 0.6rem 1.25rem;
    font-size: 0.9rem;
    font-weight: 500;
    color: var(--color-text-muted);
    cursor: pointer;
    border-bottom: 2px solid transparent;
    margin-bottom: -2px;
    transition: color 0.15s, border-color 0.15s;
}

.tab-btn.active {
    color: var(--color-primary);
    border-bottom-color: var(--color-primary);
}

.tab-btn:hover:not(.active) { color: var(--color-text); }

/* ── Batch section ───────────────────────────────────────────── */
.batch-section {
    background: var(--color-surface);
    border-radius: var(--radius);
    padding: 1.5rem;
    box-shadow: var(--shadow);
}

.batch-instructions {
    font-size: 0.85rem;
    color: var(--color-text-muted);
    margin-bottom: 1rem;
}

.batch-instructions p { margin-bottom: 0.25rem; }

.batch-example {
    font-family: var(--mono);
    font-size: 0.8rem;
    background: var(--color-bg);
    padding: 0.5rem 0.75rem;
    border-radius: 4px;
    border-left: 3px solid var(--color-border);
    margin-top: 0.25rem;
    white-space: pre;
}

.batch-input {
    width: 100%;
    font-family: var(--mono);
    font-size: 0.85rem;
    padding: 0.6rem 0.75rem;
    border: 1px solid var(--color-border);
    border-radius: var(--radius);
    resize: vertical;
    margin-bottom: 0.75rem;
}

.batch-input:focus {
    outline: none;
    border-color: var(--color-primary);
    box-shadow: 0 0 0 3px rgba(37,99,235,0.12);
}

.batch-controls {
    display: flex;
    align-items: center;
    gap: 1rem;
    margin-bottom: 1rem;
}

.batch-count {
    font-size: 0.82rem;
    color: var(--color-text-muted);
}

.batch-error {
    font-size: 0.82rem;
    flex: 1;
}

.btn-primary {
    background: var(--color-primary);
    color: #fff;
    border: none;
    padding: 0.55rem 1.25rem;
    border-radius: var(--radius);
    font-size: 0.9rem;
    font-weight: 500;
    cursor: pointer;
    transition: background 0.15s;
}

.btn-primary:hover:not(:disabled) { background: var(--color-primary-hover); }
.btn-primary:disabled { opacity: 0.55; cursor: not-allowed; }

.btn-secondary {
    background: var(--color-bg);
    color: var(--color-text);
    border: 1px solid var(--color-border);
    padding: 0.4rem 1rem;
    border-radius: var(--radius);
    font-size: 0.85rem;
    font-weight: 500;
    cursor: pointer;
    transition: background 0.15s;
}

.btn-secondary:hover { background: #e9ecef; }

.batch-results-header {
    display: flex;
    align-items: center;
    justify-content: space-between;
    margin: 1.25rem 0 0.75rem;
}

.batch-results-header h3 {
    font-size: 0.95rem;
    font-weight: 600;
}

.batch-table-wrap { overflow-x: auto; }

.batch-table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.82rem;
}

.batch-table th {
    text-align: left;
    font-weight: 600;
    font-size: 0.75rem;
    text-transform: uppercase;
    letter-spacing: 0.04em;
    color: var(--color-text-muted);
    padding: 0.5rem 0.6rem;
    border-bottom: 2px solid var(--color-border);
    white-space: nowrap;
}

.batch-table td {
    padding: 0.4rem 0.6rem;
    border-bottom: 1px solid var(--color-border);
    vertical-align: middle;
}

.batch-table tr:last-child td { border-bottom: none; }
.batch-table tr:hover td { background: var(--color-bg); }
.batch-table tr.row-error td { color: var(--color-error); }

.class-badge-sm {
    display: inline-block;
    padding: 0.15rem 0.5rem;
    border-radius: 99px;
    font-size: 0.75rem;
    font-weight: 600;
    color: #fff;
    white-space: nowrap;
}

.class-badge-sm.class-5 { background: var(--class-5); }
.class-badge-sm.class-4 { background: var(--class-4); }
.class-badge-sm.class-3 { background: var(--class-3); }
.class-badge-sm.class-2 { background: var(--class-2); }
.class-badge-sm.class-1 { background: var(--class-1); }

.criteria-cell { font-family: var(--mono); font-size: 0.75rem; }
.review-cell {
    color: var(--color-primary);
    font-size: 0.76rem;
    font-weight: 600;
    white-space: nowrap;
}
.warnings-cell { color: var(--color-warning); font-size: 0.78rem; }
.error-cell    { color: var(--color-error);   font-style: italic; }