/* ── Warnings ───────────────────────────────────────────────── */
.warning {
    font-size: 0.82rem;
    color: var(--color-warning);
    padding: 0.3rem 0;
    padding-left: 1rem;
    border-left: 3px solid var(--color-warning);
    margin-bottom: 0.3rem;
}

/* ── Footer ─────────────────────────────────────────────────── */
footer {
    background: var(--color-surface);
    border-top: 1px solid var(--color-border);
    padding: 1.5rem 0;
    margin-top: 3rem;
}

footer p {
    font-size: 0.75rem;
    color: var(--color-text-muted);
    text-align: center;
}

/* ── Responsive ─────────────────────────────────────────────── */
@media (max-width: 640px) {
    .form-row { flex-direction: column; }
    .clinical-annotation-strip {
        flex-direction: column;
    }
    .clinical-annotation-sources {
        justify-content: flex-start;
        max-width: none;
    }
    .classification-main {
        flex-direction: column;
        padding-left: 3.25rem;
        text-align: center;
    }
    .point-thermometer {
        width: 44px;
    }
    .criterion-summary-grid {
        grid-template-columns: repeat(3, minmax(0, 1fr));
    }
    .criterion-summary-grid .reason-cell {
        grid-column: 1 / -1;
        padding-top: 0.2rem;
    }
    .decision-path-svg { min-height: 320px; }
}

/* ── Narrative summary ───────────────────────────────────────── */
.narrative-section {
    background: #f0f7ff;
    border-left: 4px solid var(--color-primary);
    border-radius: 0 var(--radius) var(--radius) var(--radius);
    padding: 1rem 1.25rem;
    margin-bottom: 1.25rem;
}

.narrative-text {
    font-size: 0.9rem;
    line-height: 1.65;
    color: var(--color-text);
    margin-bottom: 0.5rem;
}

.alphamissense-row {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin-top: 0.6rem;
    padding-top: 0.6rem;
    border-top: 1px solid #cce0ff;
    flex-wrap: wrap;
}

.am-label {
    font-size: 0.78rem;
    font-weight: 600;
    color: var(--color-text-muted);
    text-transform: uppercase;
    letter-spacing: 0.04em;
}

.am-score {
    font-family: var(--mono);
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--color-text);
}

.am-class {
    font-size: 0.78rem;
    font-weight: 600;
    padding: 0.1rem 0.5rem;
    border-radius: 99px;
    color: #fff;
}

.am-likely-pathogenic { background: var(--class-4); }
.am-ambiguous          { background: var(--class-3); }
.am-likely-benign      { background: var(--class-2); }

.am-note {
    font-size: 0.73rem;
    color: var(--color-text-muted);
    font-style: italic;
}

.vus-section {
    border-left: 4px solid var(--class-3);
}

.vus-strong-pathogenic-one-step-short,
.vus-ps3-pp3-one-step-short,
.vus-pvs1-needs-support,
.vus-conflicting-pvs1-bs3,
.vus-conflicting-pp3-bs3,
.vus-mixed-benign-pathogenic-evidence,
.vus-computational-evidence-not-enough {
    border-left-color: var(--class-5);
    background: #fff5f5;
    border-color: #fecaca;
}

.vus-strong-pathogenic-one-step-short h3,
.vus-ps3-pp3-one-step-short h3,
.vus-pvs1-needs-support h3,
.vus-conflicting-pvs1-bs3 h3,
.vus-conflicting-pp3-bs3 h3,
.vus-mixed-benign-pathogenic-evidence h3,
.vus-computational-evidence-not-enough h3 {
    color: #991b1b;
}

.vus-strong-pathogenic-one-step-short .vus-next strong,
.vus-ps3-pp3-one-step-short .vus-next strong,
.vus-pvs1-needs-support .vus-next strong,
.vus-conflicting-pvs1-bs3 .vus-next strong,
.vus-conflicting-pp3-bs3 .vus-next strong,
.vus-mixed-benign-pathogenic-evidence .vus-next strong,
.vus-computational-evidence-not-enough .vus-next strong {
    color: #b91c1c;
}

.vus-strong-pathogenic-one-step-short .vus-meta,
.vus-ps3-pp3-one-step-short .vus-meta,
.vus-pvs1-needs-support .vus-meta,
.vus-conflicting-pvs1-bs3 .vus-meta,
.vus-conflicting-pp3-bs3 .vus-meta,
.vus-mixed-benign-pathogenic-evidence .vus-meta,
.vus-computational-evidence-not-enough .vus-meta {
    color: #7f1d1d;
}

.vus-summary,
.vus-next,
.vus-meta {
    font-size: 0.86rem;
    color: var(--color-text);
    margin-bottom: 0.4rem;
}

.vus-meta {
    color: var(--color-text-muted);
    font-style: italic;
}

.rna-review-section {
    border-left: 4px solid var(--color-primary);
}

.splice-ps1-review-section {
    border-left: 4px solid var(--color-warning);
}

.protein-ps1-review-section {
    border-left: 4px solid #b7791f;
}

.rna-review-section h3,
.splice-ps1-review-section h3,
.protein-ps1-review-section h3 {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    flex-wrap: wrap;
}

.priority-pill {
    display: inline-block;
    border-radius: 99px;
    padding: 0.1rem 0.45rem;
    background: #eef4ff;
    color: var(--color-primary);
    font-size: 0.7rem;
    font-weight: 700;
    text-transform: uppercase;
}

.rna-summary,
.rna-branches,
.rna-limitations,
.review-summary,
.review-branches,
.review-limitations,
.review-source {
    font-size: 0.84rem;
    color: var(--color-text);
    margin-bottom: 0.55rem;
}

.review-source {
    padding: 0.55rem 0.7rem;
    border: 1px solid #fed7aa;
    border-radius: 4px;
    background: #fff7ed;
    color: #7c2d12;
}

.rna-grid,
.review-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
    gap: 1rem;
    margin: 0.75rem 0;
}

.rna-grid ul,
.review-grid ul {
    padding-left: 1.1rem;
}

.rna-grid li,
.review-grid li {
    font-size: 0.8rem;
    color: var(--color-text-muted);
    margin-bottom: 0.35rem;
    line-height: 1.45;
}

.rna-review-section a,
.splice-ps1-review-section a,
.protein-ps1-review-section a {
    color: var(--color-primary);
    font-size: 0.82rem;
    font-weight: 600;
}

.rna-review-actions {
    display: flex;
    align-items: center;
    flex-wrap: wrap;
    gap: 0.75rem;
    margin-top: 0.75rem;
}

.manual-heading-summary {
    margin-left: auto;
    margin-right: 0.5rem;
    padding: 0.12rem 0.48rem;
    border-radius: 99px;
    background: #eef4ff;
    color: var(--color-primary);
    font-size: 0.72rem;
    font-weight: 700;
}